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SUNY Downstate Medical Center

Department of Neurology

Jin Zhou, MD PhD

Residency Information

Adult Neurology

PGY-3 Class of 2017

Education And Training

Medical School:  Jiang Medical University

Internship: SUNY Downstate


Clinical Interests: Stroke and neuro-ophthalmology
Research Interests: C
erebrovascular Diseaseautomation


Zhou J, Zhuang J, Li J, Ooi E, Bloom J, Poon C, Lax D, Rosenbaum DM, Barone FC. Long-term post-stroke changes include myelin loss, specific deficits in sensory and motor behaviors and complex cognitive impairment detected using active place avoidance. PLoS One. 2013;8(3):e57503. doi: 10.1371/journal.pone.0057503. Epub 2013 Mar 7.

 Zhou J, Li J, Rosenbaum DM, Barone FC. Thrombopoietin protects the brain and improves sensorimotor functions: reduction of stroke-induced MMP-9 upregulation and blood-brain barrier injury. J Cereb Blood Flow Metab. 2011 Mar;31(3):924-33. Epub 2010 Sep 29.

 Barone FC, Rosenbaum DM, Zhou J, Crystal H. Vascular cognitive impairment: Dementia biology and translational animal models. Curr Opin Investig Drugs. 2009;10(7):624-37.

Sánchez-Lemus E, Benicky J, Pavel J, Larrayoz IM, Zhou J, Baliova M, Nishioku T, Saavedra JM. Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen. Am J Physiol Regul Integr Comp Physiol. 2009 ;296(5):R1376-84. Epub 2009 Feb 18

Zhou J. Prospect of Neuroscience in China. Cell Mol Neurobiol. 2008 Jan;28(1):3-4. Epub 2007 Nov 28.

Macova M, Armando I, Zhou J, Baiardi G, Tyurmin D, Larrayoz-Roldan IM, Saavedra JM. Estrogen Reduces Aldosterone, Upregulates Adrenal Angiotensin II AT(2) Receptors and Normalizes Adrenomedullary Fra-2 in Ovariectomized Rats. Neuroendocrinology. 2008 Aug 4. [Epub ahead of print]

Zorad S, Dou JT, Benicky J, Hutanu D, Tybitanclova K, Zhou J, Saavedra JM. Long-term angiotensin II AT1 receptor inhibition produces adipose tissue hypotrophy accompanied by increased expression of adiponectin and PPARgamma. Eur J Pharmacol. 2006;552(1-3):112-22. Epub 2006 Sep 9.

Zhou J, Pavel J, Macova M, Yu ZX, Imboden H, Ge L, Nishioku T, Dou J, Delgiacco E, Saavedra JM. AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats. Stroke. 2006;37(5):1271-6. Epub 2006 Apr 6.

Saavedra JM, Benicky J, Zhou J. Mechanisms of the anti-ischemic effect of Angiotensin II AT(1) receptor antagonists in the brain. Cell Mol Neurobiol. 2006;26(7-8):1097-109. Epub 2006 Apr 25. 

Saavedra JM, Benicky J, Zhou J. Angiotensin II: Multitasking in the brain. J Hypertens Suppl. 2006;24(1):S131-7.

 Zhou J, Ando H, Macova M, Dou J, Saavedra JM. Angiotensin II AT1 receptor blockade abolishes brain microvascular inflammation and heat shock protein responses in hypertensive rats. J Cereb Blood Flow Metab. 2005;25(7):878-86.

Ando H, Zhou J, Macova M, Imboden H, Saavedra JM. Angiotensin II AT1 receptor blockade reverses pathological hypertrophy and inflammation in brain microvessels of spontaneously hypertensive rats. Stroke. 2004;35(7):1726-31.

Zhou J, Jezova M, Elkahloun AG, Saavedra JM. Angiotensin II AT1 receptor antagonism downregulates stress-related gene expression in brain microvessels from spontaneously hypertensive and normotensive rats. Ann N Y Acad Sci. 2004;1018:480-6.

Ando H, Jezova M, Zhou J, Saavedra JM. Angiotensin II AT1 receptor blockade decreases brain artery inflammation in a stress-prone rat strain. Ann N Y Acad Sci. 2004;1018:345-50.

Saavedra JM, Ando H, Armando I, Baiardi G, Bregonzio C, Jezova M, Zhou J. Brain angiotensin II, an important stress hormone: regulatory sites and therapeutic opportunities. Ann N Y Acad Sci. 2004;1018:76-84.

Wang LS, Zhou J, Shao XM, Tang XC. [Huperzine A attenuates cognitive deficits and brain injury after hypoxia-ischemic brain damage in neonatal rats]Zhonghua Er Ke Za Zhi. 2003;41(1):42-5.

 Wang ZF, Zhou J, Tang XC. Huperzine B protects rat pheochromocytoma cells against oxygen-glucose deprivation-induced injury. Acta Pharmacol Sin.2002;23(12):1193-1198.

Wang R, Zhou J, Tang XC. Tacrine attenuates hydrogen peroxide-induced apoptosis by regulating expression of apoptosis-related genes in rat PC12 cells.Brain Res Mol Brain Res. 2002;107(1):1-8.

Zhou J, Wang LS, Shao XM, Tang XC. Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res. 2002;949(1-2):162-70. (The first two authors are equal contributors)

 Zhou J, Tang XC. Huperzine A attenuates apoptosis and mitochondria-dependent caspase-3 in rat cortical neurons. FEBS Lett. 2002;526(1-3):21-5.

Zhou J, Zhang HY, Tang XC, Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett 2001;313(3):137-40.

Zhou J, Fu Y, Tang XC. Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation. Neuroreport 2001;12(10):2073-7.

Zhou J, Fu Y, Tang XC. Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation. Neurosci Lett 2001;306(1-2):53-6.

 Zhou J, Zhang HY, Tang XC. Huperzine A: the effective element of traditional Chinese medicinal herbs and a highly selective cholinesterase inhibitor.HerbEra 2000;1:82-99.

Zhou J, Tang XC. [Pharmacological profile and prospect of acetylcholinesterase inhibitors in Alzheimer’s disease.] Progress in Pharmacology. People’s Medical Publishing House 2001:37-51.

Zhou J, Tang XC. [Pharmacological profile of centrophenoxine in Alzheimer’s disease.] Journal of Shanghai Medical & Pharmaceutical 2001;22(8):345-351.

Zhou J, Xia CH, Huang JY. [Therapy of senile dementia and the central cholinergic system.] Jiangxi Traditional Chinese Medicine 1999;11(2):91-93.

Zhou J, Huang JY. [Pathogenesis of Alzheimer’s disease and the central cholinergic system.] Practical Geriatrics 1998;12(3):122-123.

Barone FC, Rosenbaum DM, Li J, Zhou J, Wang XKAnimal Models of Ischemic Stroke: Issues in Translational Congruency. In: "Animal Models of Diseases: Translational Medicine Perspective for Drug Discovery and Development" edited by X.K. WangBentham Science Publishers, 2012, pp. 42-66.

Member of Editorial Boards of Pharmacological Exercise. Shanghai University of Traditional Chinese Medicine Publishing House, 2000 (1st Version), 2003 (2nd version).

Member of Editorial Boards of Traditional Chinese Medicine of Anti-aging. People’s Hygiene Publishing House. 2002.

Zhou J., Thrombopoietin Reduces Brain Injury, Blocks MMP-9 Up-Regulation and BBB Damage and Improves Long-Term Neurologic Outcome Post-StrokeJin Zhou, Jie Li, Daniel Rosenbaum, Frank Barone; SUNY Downstate Med Cntr, Brooklyn, NY. International Stroke Conference Feb 2011.

Zhou J., Genetic Variations between normotensive and hypertensive in brain microvessels and potential targets of Angiotensin AT1 antagonist. Section on Pharmacology, NIMH, NIH. The Society for Neuroscience 35th Annual Meeting. Nov 2005.

Zhou, J., Rosenbaum, D.M., Willette, R.N., Lapore, J., Hu, E. and Barone, F.C.: GSK360A inhibits prolyl 4-hydroxylase, upregulates hypoxia inducible factors (HIF) and provides protection from ischemic stroke-induced injury and sensory-motor-cognitive deficitsInternational Stroke Conference (AHA), New Orleans, LA, February 1-3, 2012.

Barone, F.C., Zhou, J., Li, J., Baird, A.E., Adamski, A.G., Dow-Edwards, D.L., Bergold, P.J., Abdel Baki, S.G., Crystal, H. and Rosenbaum, D.M.: Mixed-Risk Vascular Cognitive Impairment: Hypertension plus Hypoperfusion Decrease Cognition and Gait and Increase Fiber Tract Pathology and InflammationAnnual Meeting of the American Neurological Association, Boston, MA, October 7-9, 2012.

Zhou, J., Zhang, H., Li, J., Zhuang, J., Poon, C., Rosenbum, D.M. and Barone, F.C.: Thrombopoietin Reduces Brain Injury And Cognitive Impairment In Rodent Cerebrovascular Disease Models. XXVIth International Symposium on Cerebral Blood Flow, Metabolism and Function & XIth International Conference on Quantification of Brain Function with PET, Shanghai, 2013.

Rosenbum, D.M., Zhou, J., Zhang, H.Y., Jie Li, Zhuang, J., Poon, C., and Barone, F.C.: Thrombopoietin Reduces Brain Injury and Cognitive Impairment In Rodent Cerebrovascular Disease Models. International Stroke Conference (AHA), San Diego, CA, February 12-14, 2014.